Reneall is a line of biphasic fillers based on non-animal hyaluronic acid

The Reneall product line consists of domestic monophasic fillers and biorevitalizants based on hyaluronic acid of non-animal origin, produced in Korea. What distinctive features do these injection products for aesthetic use have in comparison with their counterparts? Let's compare! So, the developer of Reneall is Russian, which is now part of the large research holding NMTC. The drug was registered as a medical product, namely a hyaluronic biopolymer (not to be confused with a biopolymer gel), approved for use in the Russian Federation in 2010. The manufacturer of the Reneall line of products, commissioned by the NMTC holding, is SLS LLC, registered in Moscow, Russian Federation. Analogues: other monophasic hyaluronic contour preparations can be considered analogues of Riniall fillers, for example: Amalian, Hyaluform, Surgiderm, Juvederm, Teosyal, Hyacorp, Style - also known as Stylage (Stylage), Belotero, CRM, Princess and so on, the list goes on due to the large selection of such tools. Analogues among biorevitalizants can be considered other drugs of this class that do not contain other active ingredients (bioreparants).

Filler Renial 200

The drug is a monophasic filler. The developer is ISS-laboratory. This is a company from Russia. The product is popular in the cosmetic field. The acid has a two-level molecular structure and is of non-animal origin.

Each package contains a glass syringe (volume 1 ml or 2 ml), needles, instructions for use, as well as stickers on the box indicating the batch number, expiration date and date of manufacture of the drug.

Active components in the product

Reneall 200 contains hyaluronic acid, formed through special cross-links. The essence of its active action is as follows:

1. The molecules are released at the first level as soon as the injection is given.
2. The activity continues for two to three months, thereby providing the main visual result of the session.
3. From the third or fourth month, the particles are broken down naturally and removed from the body, simultaneously releasing second-level molecules. This ensures that the resulting effect is maintained for another six to eight months.

In addition to hyaluronic acid, the composition contains the following components:

• purified water;
• buffer solution;
• sodium chloride (salt).

Indications for use

The main task of the drug is to replenish the missing volumes.

Filler can be used on the forehead, between the eyebrows, in the area of ​​the nasolabial folds, on the lips, cheeks (forming cheekbones), chin, and so on.

The composition moisturizes the skin well and can help smooth out crow's feet.

Contraindications for use

Renial 200 should not be administered if the patient has:

• hypersensitivity to any component of the drug;
• oncology;
• acute infectious disease;
• autoimmune disease;
• fresh rashes on the face;
• herpes;
• diabetes mellitus;
• psoriasis.

Side effects

Adverse reactions of the body can be provoked by microtraumas resulting from needle punctures of the skin. The phenomena are characteristic of almost all injection procedures, regardless of the brand of the composition.

Itching, redness, and mild pain in the treatment areas may occur. They go away on their own and do not require additional therapy.

No specific complications were observed when using the Renial 200 filler.

Analogues of Renial 200

The product's properties are similar to other HA-based fillers. These are products such as:

• Hyaluform;
• Teosial;
• Surgiderm, etc.

Reneall - physical and chemical properties of filler

Density: for Reneall products, in particular, and for biopolymers of this kind, in general, the concept of density is not of great importance (it is not measured), but the viscosity properties and the degree of cross-linking are important. Density corresponds to the density of water.

Viscosity (flow): Flowability or viscometric properties depend on the degree of cross-linking and concentration. And depending on the viscosity, the drugs are used for different purposes. The numbers in the name correspond to the increase in viscosity as they increase.

Transparency: the biopolymer in Riniall preparations is transparent and undergoes visual inspection using a special device.

Dry residue content (pH),%: 3.0 ±1.5

Extract pH value: from 6.0 to 7.5

Hydrophilicity depends on the degree of cross-linking. Less cross-linked drugs are more hydrophilic, which determines their further properties and residence time in the body.

Hyaluronic acid is a polymer that goes into solution when there is a large amount of liquid. In the case of cross-linked hyaluronic acid, the degree of swelling of a given polymer is inversely proportional to the degree of cross-linking (the more cross-linking, the less swelling). With large volumes of water and constant mechanical stress, the structure may collapse.

Riniall preparations are biphasic, but unlike restylane preparations, in this case biphasicity is ensured not by a mixture of cross-linked and non-cross-linked hyaluronic acid of the drug, but by a unique production technology. It consists of two stages. The first stage is the formation of particles of a certain size with a certain degree of cross-linking. The second stage is the formation of a single macromolecule. This makes it possible to obtain drugs with high plasticity with varying degrees of cross-linking and a longer lasting cosmetic effect.

Riniall are drugs that are homogeneous in mass. The cross-linked hyaluronic acid found in each individual syringe is one macromolecule. The production technology makes it possible to make preparations with different biodegradation times, while maintaining highly plastic properties.

Heat resistance: When heated, the drug is destroyed. This process occurs most actively after 40°C.

Light refraction and refraction: these concepts are not very important in our case, since apart from their aesthetic nature they do not have any influence on the physical and chemical properties.

Surface tension: this concept is not decisive for the physicochemical characteristics of non-crosslinked polymers, since the formation of these polymers is not associated with external processes, but with processes occurring at the level of intermolecular bonds.

The thermal conductivity properties of rinial preparations are determined by water, since 98% of the preparation component is water.

Melting point. As the temperature increases, the biopolymer breaks down into mono- and polysaccharides and glycuronic acid, then into CO2 and H2O.

Our technology allows us to obtain drugs with specified properties and high plasticity, which ensures ease of administration and the ability, with the same high plasticity, to obtain drugs with a specified biodegradation time.

Other Reneall drugs

The Renial line includes a number of drugs. These are fillers and revitalizants. They differ in density, application features and purpose.

Fillers

Among the fillers in the Renial series are:

1. Reneall 100, 1 ml. Low density composition. Used to correct fine wrinkles on the forehead, crow's feet, and also to treat the area around the mouth. It is also used by cosmetologists to fill atrophic scars.
2. Reneall 200, 1 ml. A medium-density filler allows you to replenish volume in areas where deeper folds and wrinkles have formed. Suitable for injection into the forehead and for the correction of moderately pronounced nasolabial folds. Also used to improve lip contour.
3. Reneall 300, 1 ml and 2 ml. High density product. Used to fill deep defects - folds, wrinkles. It is used to work out the cheekbones, chin, and model the volume of the face. Used to enlarge lips and improve their contour.

Revitalizants

Biorevitalizants of the brand under discussion:

1. Reneall Revitalist, 1 ml and 2 ml. Available in a syringe. The available volume of 2 ml makes it possible to carry out a full treatment of the face, neck and décolleté. The product contains single stabilization bonds, which makes it similar to the compositions of the “hydro reserve” group. The product remains in tissues for a long time and has a prolonged effect (for example, like IAL System ACP or Restylane Vital). The composition is administered deeper than other biorevitalizants. Experts recommend giving injections at the last procedure of the course in order to consolidate the effect. It has proven itself well as a drug for one-time maintenance sessions.
2. Reneall Body. The package contains 2 syringes of 2 ml each. The product is intended for the body, which is why it is produced by the manufacturer in such a volume. HA in the composition of non-animal origin, at a concentration of 20 mg/ml, is not stabilized. A cannula is supplied with the syringe.
3. Reneall Hand. An unusual solution on the revitalizant market - the composition is intended for working out the hands. The package contains two syringes with a volume of 2 ml each. The first is filler. It is characterized by a “lateral spreading” effect, which allows you to carefully and naturally fill the tissue between the vessels on the hands. The volume is enough for two brushes. The second syringe contains biorevitalizant. It has a rejuvenating effect and slightly brightens the skin.

Reneall (Riniall): side effects and precautions

As for precautionary measures, it is written for specialists who will use the drug. Regarding Reneall, for example, before the procedure it is recommended to carry out either topical anesthesia with an anesthetic cream or conduction anesthesia. It should be noted that these two methods are usually practiced, or in some cases simply applying ice is justified. With regard to tissue infiltration anesthesia, in which an anesthetic is injected into the tissue (this is sometimes used in the cheek area), the manufacturing company speaks out as NOT a recommended technique because it distorts the picture as a result of temporary deformation of the tissue. If the drug is placed deeper than recommended, it will undergo rapid enzymatic breakdown, and the time of preservation of the filler in the tissues, or biorevitalizant, is significantly reduced, and therefore, we may lose the effect. It is indicated that the administered drug may increase in volume within a few hours due to the attraction of fluid “to itself” from the surrounding tissues; this is a normal reaction that takes place within 3-4 days. It is not recommended to drink alcohol after the procedure, as this may cause swelling at the injection site.

Comparison of Reneall products

Positive feedback on the use of Renial 200

Margarita, 26 years old, Moscow:

I had lip correction done with RENEALL. I liked the result, even though the procedure was painful. The cosmetologist approached the session professionally, applied an anesthetic cream, talked about all the possible drugs, but recommended Renial 200. I agreed, since this was my first experience. In a few months I’ll be teasing more, I’ll choose the same composition. I don’t know yet how long the effect will last, but it should last 6-7 months.

Alena, 29 years old, Nizhnevartovsk:

Renial 200 helped me get rid of nasolabial folds and wrinkles on my forehead. I did it in a salon in my city. The procedure is inexpensive but very effective. Many people complain about redness after the session, but I was ready to endure such inconveniences, because they went away within a week, and I will remain beautiful for a long time.

Angelina, 5 years of professional experience, Pyatigorsk:

I am a cosmetologist and I inject Renial 200 into myself. The filler is introduced and distributed very well, there are no lumps. I numb the skin with Dr. Namb ointment.

Negative reviews

Valentina, 28 years old, Omsk:

In 2011, I decided to enlarge my lips; it was very fashionable at that time, and I had seen enough photos of Hollywood stars. I chose Renial 200 because I trusted the cosmetologist’s advice. This was a huge mistake. Immediately after the session, a huge swelling formed, not only on the lips, but on the entire lower part of the face. It was scary to return home and appear in front of my husband. The swelling went away only after a week and a half, but the lips became very hard and hurt unbearably. My suffering did not end there. The pain went away, but every 2-3 months it appeared again, in different areas of the lips. They either swollen or turned blue or purple... This condition lasted for 4 years. I will never undergo such a procedure again, much less use Renial 200.

Reneall (Reneall) – reviews:

The price of the drug is quite affordable, but it is not the cheapest product on the market. It allows you to keep the procedure at an accessible level. Tissue reactions are described by the manufacturer as 1 in 10,000. My personal experience with this drug is small, but the effect is decent, there were no problems. In fact, many (but not all) cosmetologists complain of redness at the site of Reneall injection under the influence of mild colds and sun exposure. Moreover, the prescription of the injection in some such cases is about 2 years, which indicates that the drug itself has already dissolved. What remains in the tissues and causes such things to happen? This circumstance is not entirely pleasant, and even if this does not happen to everyone, it can significantly “spoil” the opinion of the drug. As for the duration of its action, they are quite good, Riniall fillers last a long time, but what if just such an incident occurs? Now many people visit hot countries once or even several times a year, and no one needs problems during vacation. When hyaluronic monophasic preparations remain in tissues for a long time, that is, for a long time compared to their counterparts, especially those that have proven themselves to be long-used quality preparations that have undergone large-scale clinical studies (including with regard to allergenicity), this raises suspicions about that they contain some synthetic inclusions that remain in the tissues after the hyaluron has already been absorbed. They are not written about on the packaging, but such examples of pathological tissue reactivity in the projection of the filler injection site, also noted when using Radiesse and similar long-lasting drugs, suggest their presence.

Answers on questions

How much does Renial 200 filler cost?

The drug is cheaper than analogues produced in Europe, but more expensive than compounds from China. The average price in Moscow is 10,000-11,000 rubles.

Is it possible to buy the drug and take it to a cosmetologist to save money?

No. Official representatives sell products of this kind only to cosmetologists who have a medical education and a certificate for the right to work with injectable compounds.

Is it possible to get filler during pregnancy?

It is forbidden. The period of bearing a child is a strict contraindication to this type of procedure.