Hyalual preparations for skin redermalization - effectiveness and opinion of cosmetologists

Cosmetologists have long mastered working with preparations for injection contouring and biorevitalization. The ever-expanding gel market is pushing doctors to get acquainted with new drugs. The latest developments for aesthetic purposes are offered by manufacturers not only from Europe, the USA, Asia, but also from Russia and the CIS countries. For example, Ukrainian scientists presented the Hyalual line of products. The effect of the gels is not inferior in effectiveness to well-known analogues. The drugs are confidently entering the fight for a place in the arsenal of cosmetologists.

Description of the drug line

The developer of the Hyalual gel formula is considered to be the Institute Hyalual, registered in Switzerland. Preparations for intradermal administration under the brand name hyalual are produced by the Ukrainian pharmaceutical company Yuria-Pharm. The products are intended for sale in Russia and CIS countries. Products of identical composition for European consumers are produced in Italy and supplied under the name Xela Rederm.

Gels for intradermal administration Hyalual are produced on the basis of hyaluronic and succinic acids. The combination of components provides an optimal rejuvenating, revitalizing effect. For the production of substances, unstabilized sodium hyaluronate is used, characterized by a high molecular structure and non-animal origin.

Hyalual – is it worth injecting Ukrainian biorevitalizant?

Many patients, in order to save money, agree to injections of cheap gels of dubious quality, which Chinese factories generously supply us with. And almost none of them know that equally inexpensive, but much safer products are produced in the CIS countries.

Hyalual is a line of preparations based on hyaluronic and succinic acids intended for biorevitalization and redermalization of the skin. In terms of price-quality ratio, this is a good option for those who are on a limited budget. What are its main pros and cons? What active ingredients are included? What problems can be solved with their help? How long does the result last? Are there any complications or side effects? TecRussia.ru answers the most pressing questions:

↑ Information about the manufacturer

The chain of companies associated with the supply of this drug to our country is as follows:

• The developer of the formula is considered to be Institute Hyalual, an organization registered in 2009 in Switzerland. It is engaged in promoting a wide range of cosmetic products among Russian and European cosmetologists - both professional and for home care.
• The Hyalual line of injection gels is focused mainly on the market of the Russian Federation and CIS countries. It is produced by the Ukrainian Limited Liability Company "Yuria-Pharm" - a large pharmaceutical company that produces a large number of different drugs, mainly medicinal. The plant is located in the city of Cherkasy.
• Similar products are supplied to Europe under a different name - Xela Rederm. The composition is the same, but production is located in Italy.
• In 2011, the brand was registered by Roszdravnadzor as “Injectable implants based on hyaluronic acid” (registration No. FSZ 2011/10766), which fully complies with the requirements of Russian legislation.
• Further sales in the Russian Federation are carried out by the official importer - RedermaSwiss LLC, established by Institute Hyalual and closely associated with the Moscow representative office of Yuria-Pharm. The company works through a wide network of distributors, and also directly cooperates with cosmetologists and aesthetic clinics.

↑ What is included in the composition

Unlike most biorevitalizants, Hyalual gels have not one, but two active ingredients. This:

• hyaluronic acid and
• succinic acid (sodium succinate).

The HA used is unstabilized, high molecular weight, non-animal origin. Its main task is to provide deep hydration to the skin, activate fibroblast division and collagen production. The large size of the molecules (> 2.5 million Daltons) allows the drug to stay longer in the correction zone and have an intense stimulating effect on connective tissue cells.

Institute Hyalual positions succinic acid as the basis of the unique formula of its drug and its main feature. The manufacturer, and after him many cosmetologists, began to call procedures using these gels redermalization (since, unlike classical biorevitalization, it not only moisturizes the skin, but also blocks the destructive effects of free radicals). In general, there is nothing fundamentally new in this composition, since sodium succinate in combination with HA has long been successfully used in mesotherapy cocktails from various manufacturers. The main significant properties of this component:

• the ability to normalize microcirculation (including remove swelling) by reducing the permeability of the vascular wall to water and improving lymph outflow;
• pronounced antioxidant properties, thanks to which succinic acid is able to protect our cells from damage by free radicals - by the way, this is why gerontologists consider it one of the reliable and promising geroprotectors;
• normalization of energy exchange in tissues, stimulation of nutrient and oxygen consumption, protein synthesis.

At the same time, some practicing cosmetologists are confident that the amount of succinate in Ukrainian gels is so insignificant that one should not expect any noticeable effects from it - supposedly, this component is added solely for advertising purposes. Unfortunately, independent scientific research that could confirm or refute this position has not yet been carried out, however, the very fact that redermalization leads to a visible improvement in skin quality is reflected in several scientific works and articles, incl. in the works of Snarskaya E.S. and Allenova A.S. (MGMUim. I.M. Sechenov), as well as Belaya N.G. (Novosibirsk State Medical University).

↑ Line of drugs and indications for use

Hyalual brand products provide the following positive changes:

• promote deep hydration, increase skin turgor and smooth out wrinkles;
• normalize blood flow and lymph outflow, which allows you to quickly remove excess fluid and free tissues from cellular metabolic products (toxins and waste);
• reduce the severity of inflammatory reactions, incl. acne;
• moderately improve the tone of soft tissues - in combination with other care and preventive procedures, they can prevent the development of gravitational ptosis.

The line includes 3 items, differing in the concentration of HA - 1.1%, 1.8% and 2.2%. This allows the cosmetologist to work with a wide range of age-related and aesthetic problems of the patient - from unexpressed “fatigue” of the face and minor cosmetic imperfections to more noticeable facial wrinkles.

Attention! Some unscrupulous cosmetologists position Hyalual as a filler for contouring and promise patients the corresponding results - restoration of soft tissue volume, filling of nasolabial folds, etc. This is impossible: the characteristics and concentration of hyaluronic acid in the composition of the drug do not allow such radical changes to be achieved. Its main task is to moisturize the skin and improve its quality, but to fight deep wrinkles or, for example, to enlarge lips, you should use completely different means specifically designed for this.

↑ How the procedure is performed

Redermalization Hyalual is not much different from the introduction of biorevitalizants from other brands. It is performed according to the following algorithm:

• identification of indications and possible contraindications, selection of the required concentration and volume of the gel;
• pain relief using products for external use (sprays and ointments with lidocaine, novocaine or other local anesthetics);
• disinfection of the skin in the planned injection area with solutions of antiseptics such as Miramistin;
• administration of the drug using the selected technique - either papular or linear;
• monitoring the patient in the first 0.5-1 hour to exclude the development of complications. At the same time, measures are taken to minimize swelling.

For several days after the procedure, it is recommended to avoid thermal and mechanical effects on facial tissue, reduce physical activity, and treat skin puncture sites with antiseptic solutions. For more information about the restrictions, see the article “What you can’t do after biorevitalization.”

The standard course consists of 3-4 sessions, which are held at intervals of three weeks. Normally, positive changes appear a few days after the first injections, but final conclusions should be made only after completion of all planned procedures. But how pronounced the result will be and how long it will last is very individual. It all depends on the initial condition of the skin and the external conditions in which the patient lives. Typically, cosmetologists recommend conducting at least 2 courses of biorevitalization per year, as well as 1-2 preventive sessions before and after trips to hot countries.

• For maximum effectiveness, the manufacturer suggests using parallel home care products from the Hyalual series - light moisturizing serums and creams. Obviously, in this case there is not much point in becoming attached to a brand and any other products with a similar composition will be suitable for the same purposes.

↑ Contraindications, possible complications and side effects

Biorevitalization with this and any other drugs is not carried out in the following cases:

• the presence of active inflammation in the intended injection area;
• blood clotting problems;
• increased convulsive readiness;
• during the course of acute infectious diseases, exacerbation of existing chronic health problems;
• individual intolerance to hyaluronic acid;
• polyvalent allergy;
• the patient's minor age;
• pregnancy and lactation period.

In most cases, Hyalual injections are accompanied by the expected side effects:

• redness at injection sites;
• a feeling of fullness when a large amount of the drug is administered locally;
• swelling, which can increase over 1-2 days;
• the appearance of small hematomas;
• characteristic papules on the skin.

All these consequences are considered a normal tissue reaction to the procedure and, as a rule, go away on their own.

In addition, in reviews of cosmetologists and patients about this drug, allergic reactions are mentioned more often than usual - we are mainly talking about the appearance of harmless, but rather unpleasant swelling on the face. At the same time, there is no scientific evidence that succinic acid or hyaluronate can provoke a similar effect.

• What side effects and complications occur after biorevitalization? What should the patient do? The cosmetologist tells

Most experts believe that the reason is protein impurities present due to insufficiently thorough purification of hyaluronic acid. This is a common problem with economy-class injection gels; it does not pose a great danger, but those who are initially prone to allergies should do a skin test before using Hyalual for the first time. It is also worth considering that these facts are presented in the form of anonymous private opinions, without direct evidence, and may turn out to be just another form of unfair competition.

↑ How much does redermalization cost? Current prices

Attention! The cost of procedures with this drug is noticeably lower than when using European or other high-quality foreign biorevitalizants. Because of this, it is very popular among those who cannot yet purchase products from more expensive brands - these are beginners with little experience, as well as professionals without medical education who perform injections at home. Therefore, the choice of a doctor in this case should be approached especially carefully (in particular, redermalization is carried out in such reputable institutions as the “Clinic of Professor Yutskovskaya” and the “Institute of Plastic Surgery and Cosmetology on Olkhovka”).

↑ Conclusions TecRussia.ru

• The Gialual line of biorevitalizants is registered in full compliance with the legislation of the Russian Federation and is produced by a large company with a good business reputation.
• The price is affordable, comparable to inexpensive biorevitalizants of Asian origin, and unlike most of the latter, the drug is registered with Roszdravnadzor as a medical product - this means that an independent expert organization has conducted the necessary amount of clinical research that has confirmed its quality and safety.
• Reviews about the application and results are mostly positive.
• The main competitive advantage of the drug, in our opinion, is its good price/quality ratio. We recommend trying Hyalual for those who want to save as much as possible on “beauty injections” without additional risks to their health. As an alternative, you can pay attention to the relatively inexpensive, but well-proven Russian Hafiller Aqua and Gialuform. And for those who are less strapped for money, we suggest that you familiarize yourself with our rating of the best drugs for biorevitalization.

Indications, effectiveness of use

The use of Hyalual products is characterized by the following beneficial effects:

• deep hydration, normalization of skin turgor;
• cleansing, healing of cellular structures;
• anti-aging balancing of tissue quality (smoothing wrinkles, tightening sagging);
• promoting skin sanitation (healing inflammation, stabilizing the sebaceous glands, correcting scar tissue, eliminating excessive pigmentation);
• optimization of internal processes (normalization of blood flow, lymph outflow, stimulation of the production of own collagen, elastin).

Hyalual preparations are prescribed for support, reconstruction, and tissue rejuvenation according to indications. The complex effect of Hyalual products is called redermalization by cosmetologists. People turn to the procedure when trying to get rid of visible aesthetic problems and improve the quality of the integument.

Depending on the option used for intradermal injection of Hyalual, cosmetologists perform preventive biorevitalization and light injection contouring. Hyalual gels allow you to work with a wide range of age-related and aesthetic deficiencies of the patient. Happens:

• “revival” of tired skin;
• elimination of wrinkles;
• light tissue tightening;
• correction of cosmetic defects.

Note! Redermalization with Hyalual is performed on patients over 25 years of age. The optimal age for regular procedures is 35–45 years. Injection correction is performed as an independent intervention, a preparatory stage for more serious manipulations affecting the deeper layers of the skin.

Drug review

During Hyalual biorevitalization, an amazing effect is achieved - the skin is noticeably transformed, becoming smoother and more elastic, with a pronounced healthy glow.

Additionally, wrinkles are smoothed out, the production of collagen and elastin is stimulated, and some aesthetic defects in appearance caused by time and environmental factors of an aggressive nature are corrected.

Correction is allowed at the age of 25+. Regular use is only permissible after 35.

Result of the procedure:

• the color improves and the skin texture is evened out;
• elimination of wrinkles;
• restoration of turgor;
• light face lift;
• cleansing, healing of cellular structures;
• inflammation and scars disappear;
• the functioning of the sebaceous glands is normalized.

Compound

The high effectiveness of dermal fillers is due to the unique ratio of active substances.

The formula developed by the manufacturer is considered exclusive and allows you to achieve maximum rejuvenation effect. The complex effect ensures tissue reconstruction.

Buyanov Sergey Yurievich (Expert Doctor):

Hyalual products are called “rejuvenating apples” because the product contains stem cells from wild Swiss apple fruits.

Contains:

• Succinic acid (sodium succinate). Concentration 16 mg/ml;
• Hyaluronic acid derived from the synthesis of non-animal raw materials. The concentration may vary depending on the drug.

Manufacturers

The development of the innovative formula of dermal gels for biorevitalization belongs to the Swiss developers Institute Hyalual, however, for distribution in Russia and the CIS countries, the line of drugs is produced by the cosmeceutical company Yuria-Pharm, located in Ukraine.

In Europe, these biorevitalizants with an identical composition are also produced by a cosmetology concern in Italy, differing only in the name of the collection - Xela Rederm.

Types of gels

The classification of drugs in the Hyalual line is based on the division of substances according to the level of concentration of sodium hyaluronate. The manufacturer offers patients 3 types of gels:

• Hyalual 1.1%. The drug belongs to soft substances suitable for biorevitalization. The gel is used to prevent age-related changes, strengthen, and improve tissue health. The product helps eliminate a tired appearance, clear acne from the skin, and remove the emerging network of small expression wrinkles. The procedure using the substance is prescribed to young patients (25–30 years old). At an older age, the product is used to prepare the skin for deep peelings, plastic surgeries, and during the recovery period after various interventions.

• Hyalual 1.8%. A substance of medium density, used for prevention and elimination of age-related changes in patients over 35 years of age. This option helps smooth out wrinkles, minimize folds, and achieve a slight lifting effect.

• Hyalual 2.2%. The product is used to correct pronounced wrinkles, folds, oval tightening, and light volumizing modeling of the face and body. Changing contours with gel and natural lip design are popular. The drug has a strong anti-aging effect: it eliminates noticeable sagging tissue.

Hyalual products are designed to work with skin quality. It will not be possible to achieve a significant change in appearance by increasing volume with gel. Hyalual products are used as a stimulating anti-age complex.

Description of varieties

Hyalual has a fairly wide range of uses.

Serums can also be used to redermalize the skin. In this regard, the work of epithelial cells is activated, and the effect of the biorevitalizant is enhanced.

The series is represented by several products in which succinic acid remains unchanged, and the level of hyaluronate fluctuates. Moreover, some drugs are suitable not only for invasion, but also for external use.

Hyalual 1.1%

The softest product in the entire line. Designed for people aged 25-30 years.

It helps prevent the first signs of the appearance of a network of fine wrinkles and give the skin a healthy and fresh appearance. It is distinguished by its anti-inflammatory and decongestant properties, which minimizes the occurrence of side effects after major surgery.

For older age groups, biorevitalizant is used in preparation for plastic surgery or before deep cleansing of the face.

As a result of lymphatic drainage, excess fluid is removed from the intercellular space and a lifting effect is achieved.

Dermal gel is injected into the subcutaneous layers using the papular technique.

Hyalual 1.8%

Intended for the age group of 35 years and older as a prophylactic agent or for the correction of aesthetic defects.

Thanks to injections, a noticeable rejuvenation of the dermis occurs, wrinkles are filled in and post-acne problems are eliminated.

Additionally, during the invasion, facial modeling can be performed in the areas of the cheekbones and nose. Filler is also used to enlarge lips.

When the filler penetrates the connective tissue, the processes of elastin and collagen production are launched, and blood microcirculation is accelerated.

Hyalual 2.2%

The densest filler from Hyalual. The concentration of haluronic acid is 22 mg/ml.

Designed for people aged 40-45 years. It is additionally used as a prophylaxis against photo- and chronoaging.

The drug provides a lifting effect. During the procedure, facial features are sculpted, pronounced wrinkles are eliminated, and a protective barrier is created against dehydration of the epidermis.

Hyalual Artro (Artro)

A unique gel for eliminating joint problems. It has good viscosity indicators. Indicated for administration inside the joint.

In most cases, three injections are enough to relieve pain, minimize inflammation and reduce stiffness during movement.

The effectiveness of hyaluronic acid is due to its ability to have a beneficial effect on the fluid inside the joints.

Succinic acid, in turn, promotes the correct course of physiological processes and stimulates regeneration at the cellular level.

Hyalual Daily Deluxe

The product in spray form is intended for external use. Suitable for any skin type. Available in volumes of 50 ml or more.

Recommended as a daily preparation for the care of the dermis in the presence of small wrinkles and their prevention.

As a result of regular application, the tone of the epithelium is normalized, the appearance improves, wrinkles are smoothed out, and additionally has an antioxidant effect.

Hyalual Wow eyes

An express remedy for solving aesthetic defects in the periorbital area.

Allows you to cope with puffiness under the eyes, dark circles, bags and a fine network of wrinkles.

The kit includes patches (2 pcs.) - each of them can be used 7 times, as well as a storage container.

Hyalual Safe Sun

A cream aimed at protecting against sun and UV rays, the effect of which can lead to the appearance of certain dermatological diseases and burns.

Suitable for light sensitive skin.

Regular use guarantees a reduced risk of flaking, maintains skin elasticity and prevents premature aging.

Hyalual Wow mask

Rejuvenating hydrogel mask based on peptides. Acts at the cellular level thanks to the RMСP complex.

Buyanov Sergey Yurievich (Expert Doctor):

The principle of TCD technology is used - transdermal cosmetic delivery, which involves triggering the action of active substances when the product is heated to the temperature of human skin.

Allows you to cope with age-related changes by filling skin cells with missing moisture. The effect is noticeable after the first use.

Purchasing drugs

Injection gels are packaged in syringes of 1 or 2 ml. The box, in addition to the hermetically sealed substance, contains instructions with a description of needles of the recommended size. You can purchase Hyalual preparations in many online stores. Gel Hyalual 1.1%, depending on the volume, can be purchased for 3100-4500 rubles, Hyalual 1.8% - for 3900-5500 rubles, Hyalual 2.2% - for 4300-6000 rubles.

For home use, Hyalual offers perfoskin home (prederm + device). The set consists of a syringe with gel and a disposable mesoscooter. The cost of the kit is approximately 2.5 thousand rubles. Prices vary slightly at different retail outlets. To obtain guaranteed quality products, it is recommended to make a purchase through an online store on the manufacturer’s official website.

Carrying out the redermalization procedure

Redermalization is a very conventional name for the procedure. The course of manipulation is no different from classical biorevitalization. The difference is in the composition of the substance administered. The combination of sodium succinite (succinic acid) with sodium hyaluronate in the gel allows you to rename the procedure.

The session follows a standard scheme for similar interventions:

1. Classic skin cleansing, use of antiseptic.
2. Performing anesthesia (the step is additionally agreed upon with the patient). The cosmetologist will offer an anesthetic cream or injection. The procedure can be performed without anesthetic.
3. Injection of the gel to a certain depth. Injection parameters are determined individually. The value depends on the type of product used, the area being treated, and the individual characteristics of the patient. The cosmetologist uses a thin flexible needle to evenly distribute the substance under the skin. The processing technique depends on the tasks assigned. Additional gentle massage of the areas by a cosmetologist is possible. This will help to better disperse the dense consistency of the gel.
4. Final antiseptic treatment. Additional use of emollient, wound-healing, and anti-inflammatory agents is possible.

The Hyalual filler injection procedure takes 20–60 minutes.

Important! To obtain optimal results, it is recommended to undergo a course of interventions: from 3-4 sessions, evenly distributed over 3 months.

How does the procedure work?

The chronology of the cosmetologist’s actions includes the following steps:

1. Removing makeup.
2. Disinfection of the skin with an antiseptic agent.
3. Applying a pain reliever, such as Emla cream.
4. Opening the package with the filler, presentation by the cosmetologist of the integrity of the bottle and checking the expiration dates. Preparing the syringe.
5. Injection of the product in the designated area of ​​influence.
6. Additional disinfection.

Administration techniques

Papular: insertion of the needle at a maximum angle of 30 degrees with an upward cut. The depth of penetration of the tool should not exceed 2 mm. As a result of manipulations, convex papules are formed in which the active substance accumulates. Symptoms disappear after a few days.

Linear: involves deeper insertion along the dermal defect - so that the convexity of the instrument itself can be discerned through the skin. The drug is administered at the moment the needle comes out.

The choice of method depends on the use of a particular product.

• Hyalual 1.1% - is introduced into connective tissues exclusively by the formation of papules.
• Hyalual 1.8% - papular technique is used only for body correction, linear - in the face area.

Course duration

The duration of the course depends on the task and the individual characteristics of the patient. Infestations occur at intervals of a couple of weeks.

Healing period

Tissue injury when injecting Hyalual products is superficial. The rehabilitation period after the procedure is conditional. Often negative manifestations are limited to the severity of papules, slight swelling, redness, and bruising. Symptoms disappear within 2–5 days.

Masking side effects is not recommended. The doctor will warn you about the need to abandon standard washing and use of any cosmetic preparations on the first day. Skin care during the remaining days of the recovery period is no different from usual.

The cosmetologist will point out the importance of observing restrictions. Bans last 2–7 days. It is forbidden:

• rub and massage the skin vigorously, it is advisable to touch the affected areas as little as possible;
• swim in public places with potentially dirty water (swimming pool, open water);
• warm up (steam), supercool the skin (wash with hot water, steam, stay in the cold for a long time, be exposed to sudden temperature changes);
• experience exposure to ultraviolet radiation (sun, solarium);
• carry out various procedures without the approval of a cosmetologist.

The positive effect of Hyalual products is noticeable after 3–5 hours: the skin becomes velvety, minor irregularities are smoothed out. After 3–5 days, the face takes on a fresh, healthy appearance, and signs of fatigue are eliminated. The tissues become toned and tightened. The positive effect increases with the course of procedures. The result lasts 6–12 months. If the deficiencies return, the course is repeated.

Neutralize the effect

The need to neutralize or minimize the result obtained from the intradermal administration of Hyalual products usually does not arise. Redermalization with Hyalual preparations gives a mild, gradually increasing positive effect.

The unsatisfactory result of light volumization with the dense version of Hyalual can be corrected with the help of products with hyaluronidase activity, a course of physiotherapy, and regular visits to the sauna and gym.

A doctor will help eliminate negative achievements in the form of allergies and inflammation. In such cases, antihistamines and anti-inflammatory drugs are prescribed.

Precautionary measures

Before performing the procedure, the doctor is required to conduct a consultation to make a decision about the possibility of intervention. The cosmetologist collects anamnesis, which helps to identify contraindications:

• skin damage, active inflammation in affected areas;
• impaired blood clotting;
• predisposition to seizures;
• exacerbation of chronic disorders, active course of any disease;
• period of pregnancy, breastfeeding;
• oncology, severe endocrine, somatic, cardiovascular abnormalities;
• individual negative reactions to the components of the gel.

Attention! It is not recommended to perform the intervention if the patient is not feeling well, during menstruation, or if there is a tendency to keloid scars.

Side effects are minimal when performing redermalization. Swelling, bruising, and discomfort in the areas of tissue filling are possible. The symptoms are minor and go away on their own within 2–5 days. The severity of punctures, papules, redness, and discomfort are noticeable for 2–5 hours. If side effects persist for a long time, are pronounced, or are extensive, it is recommended to additionally consult with a cosmetologist. You should be concerned if:

• inflammation;
• tissue numbness;
• severe pain;
• allergic reactions.

Consulting a doctor with such symptoms is mandatory. The cosmetologist will prescribe treatment, minimizing possible negative consequences.

Contraindications

The price for Gialual is quite high, and the course is long, so you need to know the basic contraindications. In clinics with a good reputation, the client is warned in advance when a particular course is a priori prohibited. Here is a list of conditions, symptoms and syndromes when gilahual is prohibited:

• for chronic hypertension;
• for endocrine problems;
• for malignant tumors;
• for autoimmune problems;
• for hemophilia and the prescription of anticoagulants;
• with severe acne;
• for central nervous system disorders;
• for individual allergies.

Opinion of cosmetologists

Doctors use Hyalual in their work, but even dense filler options are equated to biorevitalizants. Cosmetologists use the drugs on a par with more well-known, recognized brands of products for intradermal injection, but call the combination of price and quality unreasonable.

The cosmetologist did not like Hyalual.

The cosmetologist likes Gualual, like other, more well-known drugs.

The cosmetologist likes the line, but considers the price too high.

Patient reviews

The use of Hyalual products has not gained mass popularity. Many patients do not trust the composition and the manufacturer. After using Hyalual products, patients’ opinions often change: the drug shows high effectiveness as a biorevitalizant. There are cases of negative reactions to the use of the substance.

The patient likes the effect of Hyalual products.

The patient received severe swelling after the Hyalual injection procedure.