Revanesse fillers are produced by the famous Canadian pharmaceutical company Prollenium Medical Technologies. These preparations based on hyaluronic acid are popular among cosmetologists around the world. They are used for biorevitalization and contour plastic surgery.
All products in the line are based on stabilized hyaluronic acid of non-animal origin. It is obtained in a special way - by bacterial fermentation. This production method ensures complete safety for humans and the purity of the drug. Before using Revanesse fillers, you don’t even need to do allergy tests.
General characteristics
Fillers are represented by a wide range of injectable products: Revanesse, Revanesse Pure, ReDexis, ReDexis Ultra, Revanesse Ultra, Revanesse Contour, Revanesse Kiss (Lips).
The main feature of the entire line is the presence of hyaluronic acid. The concentration of the component increases due to the lengthening of the chain.
Particles of hyaluronic acid act as springs that have an effect in smoothing out wrinkles. After the first session, patients observe positive changes.
Answers on questions
Does filler contain an anesthetic?
Yes, some drugs contain lidocaine (for example, Revaness Kiss contains it). The use of concomitant anesthesia is not required with it.
How often do refresher courses need to be taken?
It all depends on the individual characteristics of the body, the area being treated and the degree of degradation of hyaluronic acid. For example, to correct your lips, you need to visit a cosmetologist once every six months.
How many injections are needed to get the desired effect?
It depends on the type of filler and the affected area. When using Revanesse Kiss, one injection is enough. If you use Revanesse Pure, you will need 4 sessions spaced 30 days apart.
Types of fillers
Revaness presents a line of 7 gel options.
Revanesse Pure
Pure injection gel for biorevitalization is used on problem areas of the face, neck, décolleté and arms. The drug is injected into the superficial layer of the dermis.
It spreads easily, restores healthy tone, moisturizes and restores skin elasticity.
Suitable for correcting fine wrinkles and eliminating unevenness. Gives the face a fresh look and perfectly moisturizes.
Monophasic gel combines well with other products in the Revaness line. It completely decomposes and is eliminated within six months.
Revanesse
Injections with the drug are intended for correction of the neck, arms, and face. The gel does an excellent job of removing crow's feet and smoothes out nasolabial folds. It is injected into the middle layers of the skin.
The effect of the drug lasts for six months, complete dissolution occurs after 9 months.
ReDexis
Redexis fillers contain hyaluronic acid and dextranomers in a ratio of 50 to 50%. The latter help the body produce its own collagen. Indications for injections will be medium and deep wrinkles on the face: in the eyebrows, eyes, nose and lips.
The drug is administered subcutaneously; it dissolves only after 1.5 years.
Buyanov Sergey Yurievich (Expert Doctor):
The technology of cross-linking hyaluronic acid molecules “THIXOFIX” allows you to obtain a three-dimensional, especially strong thread. Dextranomer is a glucose polymer that enhances the attraction of moisture and serves as a link between collagen and elastin molecules, attracting them to each other - this is how threads are formed that are not destroyed even after the end of the drug.
ReDexis Ultra
A double amount of dextranomer is aimed at activating the synthesis of your own collagen.
Redexis Ultra injections are aimed at smoothing out deep wrinkles and folds. The product helps to correct the volume and shape of the cheekbones, chin and nose.
The period of complete dissolution in the body is 2 years.
Revanesse Ultra
Thick gel produced by the Thixofix cross-linking process. The action of Revaness Ultra is aimed at smoothing out medium and deep wrinkles. With its help, the contours of the lips are corrected, the shape of the chin is changed, and the cheekbones are enlarged. The drug is widely used in non-surgical rhinoplasty and intimate plastic surgery.
The product is widely used to eliminate deep expression and age wrinkles in the lips, eyes, forehead and nose. Injected into the middle and deep layers of the dermis.
Completely dissolves in 9 – 12 months.
Revanesse Contour
The high-viscosity product is designed to add volume to the cheeks, forehead and chin, eliminate facial wrinkles, contour and enlarge the lips. It is also actively used for figure correction: correcting the contours of the buttocks, arms, chest, etc. It resolves after one and a half to two years.
Revanesse Kiss (Lips)
The action of the Revaness Kiss filler is aimed at adding volume to the lips and correcting their shape.
Ease of administration
The high plasticity of the Revanesse and ReDexis line of drugs is determined by the patented technology for cross-linking HA molecules - Thixofix®, which allows the binding of high molecular weight HA. Thanks to this technology, Revanesse and ReDexis fillers have the properties of a thixotropic liquid: under normal conditions, they are high-viscosity gels. Under the influence of pressure (such as the force of a piston during injection), their viscosity decreases, which allows the filler to be easily and effortlessly injected through a thin needle without damaging the modified HA particles. When they enter the tissue, the fillers return to their original highly viscous state. In addition, our syringes have wide finger grips and an extended plunger for easier operation. The new syringe design provides the doctor with greater flexibility during injection.
Comparative table of drugs
| Hyaluronic acid concentration (mg/ml) | Application | Insertion depth | Effect duration | |
| Revanesse | 25 | shallow wrinkles and irregularities (facial wrinkles, “crow’s feet”); correction of earlobes and chin; nasolacrimal strip filling | middle layers of the dermis | 6 months |
| Revanesse Pure | 15 | elimination of fine wrinkles and irregularities on the skin of the face, hands, neck, décolleté | superficial layers of the dermis | 6 months 9-12 months |
| Revanesse Ultra | 25 | deep and medium wrinkles; correction of the nose, lips, cheeks; intimate plastic surgery | middle and deep layers of the dermis | 18-24 months |
| Revaness Countour | 25 | visible signs of skin aging; correction of some parts of the body (buttocks, arms, chest) | middle and deep layers of the dermis | 18-24 months |
| ReDexis | 25 | deep wrinkles in the nose, forehead, near the mouth, eyebrows | middle and deep layers of the dermis | 12-18 months |
| ReDexis Ultra | 17 | correction of the shape of cheekbones, cheeks, forehead, nose | middle and deep layers of the dermis | 18-24 months |
| Revaness Kiss | 14 | adding volume and correcting the shape of the lips | lip area | 25 months |
Revaness line
Revanesse is a range of high HA (25 mg/ml) injectable fillers manufactured using state-of-the-art manufacturing methods and high quality materials that have undergone rigorous testing and quality control.
Revaness products are designed for:
- Correction of fine and deep wrinkles;
- Replenishment of tissue volume deficit;
- Formation and restoration of facial contours
- Volumetric modeling
- Deep skin hydration.
Indications for use
Practice shows that procedures for skin rejuvenation and eliminating age-related problems with the help of fillers are chosen by women after 30. At this stage, the skin experiences a moisture deficiency, which significantly affects its condition.
Injection injections Revanesse Kiss., Redexis and Redexis Ultra are more suitable for 35-year-old patients.
The Canadian line covers a fairly wide range of age and aesthetic problems. With injections you can:
- smooth out facial skin, smooth out wrinkles of any depth;
- lift the corners of the mouth, correct lip asymmetry and increase volume;
- get rid of crow's feet;
- eliminate nasolabial and glabellar furrows;
- adjust the proportions of the oval of the face;
- moisturize, smooth and rejuvenate the skin;
- improve complexion.
Biorevitalization and contour plastic surgery are allowed only after 18 years of age.
Advantages of the Revaness line
- Fillers are comfortable and flexible to work with.
- They are of high quality, confirmed by FDA studies.
- All gels are absolutely safe and hypoallergenic.
- They have a long-lasting effect due to the slow biodegradation of the active component, so the rejuvenating effect lasts quite a long time.
The effectiveness and duration of action depend on the chosen drug and area of application. The average is from 6 months to 1 year.
After this period, hyaluronic acid is eliminated from the body naturally. If desired, you can take a repeat course.
Which is better for lips: Revaness, Juvederm or Restylane
The main difference between all three drugs is their composition. Juviderm appeared on the cosmetology market quite a long time ago and has proven itself very well. Its advantage is the anesthetic component in the composition. In addition to lip augmentation, filler helps smooth out fine wrinkles around the mouth.
Restylane has several types of fillers for correcting the shape of the lips (read our tips on how to change the shape of the lips): Restylane Lip Volume (to increase volume) and Restylane Lip Refresh (to rejuvenate the skin of the lips and smooth out fine wrinkles around the mouth). The effect lasts for an average of six months.
Revanesse Kiss filler with hyaluronic acid is considered the undisputed leader. It has a low likelihood of developing side effects. The special structure of hyaluronate in the composition ensures high efficiency and prolonged action. Another advantage is the low price and the fact that the desired effect can be achieved in just one procedure.
Purchasing drugs
Only cosmetologists can buy the Revaness product, so information about the price is not publicly available.
You can find out the cost on the online store website only after registration and confirmation of medical education in this profile.
According to some sources, the cost of one package (2 syringes of 1 ml of the drug) is 9,000 - 10,000 rubles.
But there is a huge plus here - it is guaranteed to avoid counterfeiting. Surely the clinic where you are going to undergo the procedure has a communication channel with the official distributor.
Contraindications for carrying out
Revaness fillers have a whole range of advantages, but there are still restrictions on the procedure.
These include:
- age under 18 years;
- pregnancy and breastfeeding;
- malignant tumors;
- herpetic infection;
- poor blood clotting;
- viral and infectious diseases;
- autoimmune disorders;
- skin damage (scratches, wounds) in the intended impact area.
Buyanov Sergey Yurievich (Expert Doctor):
For diabetes mellitus of any type, it is undesirable to use drugs containing dextranomers consisting of glucose molecules. The glucose depot in the skin creates an additional burden and requires an increase in the dosage of sugar-lowering drugs.
Cosmetologists do not recommend planning the procedure on the expected days of your period. At this time, women have an increased pain threshold and blood clotting is impaired.
Revanesse Contour
Revanesse Contour is a completely biodegradable transparent hyaluronic acid gel of ultra-high viscosity. It is specially designed for volumetric facial modeling. The gel is ideal for replenishing volume deficit in the middle third of the face, enlarging the cheekbones and chin, and restoring the clarity of facial contours.
Ideal for creating clear facial contours and replenishing tissue volume deficits.
Indications for use of Revanesse Contour
The product is necessary to carry out tissue reconstruction. Patients will be able to restore the natural contour of their face. With the drug you will be able to cope with defects that have arisen due to HIV-associated lipodystrophy or lipoatrophy. The product is actively used in cosmetology. With it you can restore volume, get rid of facial wrinkles, moisturize the skin, and enlarge lips. The drug allows you to overcome depression of soft tissues.
What are the contraindications for Revanesse Contour?
- Do not inject the drug into the skin around the eyes.
- The product should not be used by patients with a tendency to form scars.
- The product is prohibited for use by persons under 18 years of age.
- Revanesse Contour is not used during pregnancy or breastfeeding.
You should first discuss the use of the product with a professional cosmetologist.
Side effects
Sometimes after contouring, the patient experiences mild side effects.
They usually go away on the 7th day after the procedure. It can be:
- redness and slight bruising;
- swelling;
- pain at the injection sites or slight itching;
Situations that require immediate medical attention and treatment include:
- long-term loss of skin sensitivity at injection sites;
- scarring of tissue in the injection area;
- formation of compactions and bumps;
- skin discoloration;
- filler contouring.
Health safety
Many clinical studies have proven the complete safety of Revaness fillers. They are considered hypoallergenic and do not cause any side effects. Hyaluronic acid is of non-animal origin, which eliminates the possibility of infection.
All drugs are highly biocompatible, do not have a negative effect on natural metabolism in tissues, and do not move beyond the implantation area.
Negative reviews of fillers are associated with the rapid breakdown of gel components under the action of the enzyme hyaluronidase. Each patient produces a certain amount of this enzyme; under its action, the drug can be dissolved almost instantly. Unfortunately, it is not possible to influence this.
Stages of the procedure
First of all, the patient needs to decide on a clinic to provide the appropriate service and choose a specialist. This choice should be approached very responsibly.
Only a qualified cosmetologist can perform Revaness injections. He must have a certificate and license to operate.
Preparation
The procedure is preceded by a preparatory stage lasting several days. It consists of the following steps:
- Examination by a cosmetologist. The patient gets acquainted with the specialist, a visual examination is carried out and the issue of choosing an injection is decided.
- Passing a medical examination. This is a mandatory procedure that helps to identify the presence or absence of health problems in order to eliminate the risk of complications and side effects.
- Preparation for the procedure (starts 3-4 days before the correction). It involves quitting smoking and alcohol, stopping taking certain medications, and refusing to visit the steam room and solarium.
Introduction technology
The entire procedure lasts about 15 minutes. If a specialist treats a large area, the correction may take longer.
Stages:
- Cleansing and disinfecting the skin, marking areas for injections.
- Use of anesthesia (as needed and desired by the patient).
- Opening the package. This happens in such a way that the patient sees its integrity. Until this moment, the drug must be kept at room temperature for half an hour. The drug is used once, otherwise there is a high risk of developing serious complications.
- Before directly introducing the gel, the cosmetologist presses on the piston until a drop of gel appears at the tip of the needle.
- Administration of the drug. The process techniques are varied; the specialist himself will determine the appropriate one.
- Disinfection after injection. Tips for caring for the treated area.
For injections, only thin needles are used. No saline solution is required to dilute the gel. The drug is injected to a certain depth slowly and carefully. After administration, lightly massage the treated area.
Duration of action
The validity period of the Revaness line gels depends on the chosen product and area of application.
On average, from 6 to 24 months. At the end of this period, biodegradation and removal of hyaluronic acid from the body occurs.
Photos before and after
How is the healing period going?
Minor visible consequences (swelling, redness, bruising) disappear within a few days, less often within a week.
During this period, you should follow simple recommendations:
- protect the affected area from sunlight and temperature changes;
- do not touch the injection sites with your hands, do not scratch or rub;
- if the face area is affected, then there is no need to apply makeup for a day or two;
- You should not visit the solarium and bathhouse/sauna, limit physical activity, and exclude sports.
Lead a healthy lifestyle for several months: adjust your diet, take vitamin complexes, limit alcohol consumption, etc.
Multicenter comparative study of Revanesse Ultra and Restylane
Multicenter, double-blind, randomized comparative evaluation study of the effectiveness and safety of Revanesse® Ultra and Restylane® in the correction of nasolabial folds.
Authors: Dr. Melvin Elson, Dr. Sheldon Pollack, Dr. Sylvia Garnis-Jones, Dr. Lisa Kellet.
One hundred and forty-two (142) patients agreed to participate in the study, of which 130 patients were administered both Revanesse® Ultra and the control drug. All 130 people treated were included in the safety analysis. Some of the patients who completed the study (N = 118) participated in the primary efficacy analysis.
The effectiveness analysis was carried out on 118 patients over a period of 6 months. The number of patients lost to follow-up was small (9%), which did not affect the study results or conclusions.
Cost of the procedure in clinics
According to available information from price lists of salons, clinics and medical centers, the average price for a procedure using Revaness injections ranges from 8,000 to 12,000 rubles, biorevitalization - from 18,000 rubles.
The price depends on the qualifications of the cosmetologist, the location of the clinic or salon, as well as the amount of the drug used for the treated area.
In the regions, prices are significantly lower than in the capital and large cities of Russia.
conclusions
Efficiency
Revanesse® Ultra met the primary efficacy endpoint when compared with control, as assessed by the Wrinkle Severity Score (WSRS) after 6 months.
Revanesse® Ultra also met all secondary endpoints and found that Revanesse® Ultra performed comparable to control when assessed using the General Aesthetic Improvement System (GAIS) by physician and patient, as well as when assessed by scale. wrinkle severity (WSRS) by the patient.
Each of the three blinded investigators independently rated Revanesse® Ultra the same as in the report. Additionally, one blinded investigator assessed efficacy using the photograph-based Wrinkle Severity Score (WSRS) and the Global Aesthetic Improvement System (GAIS), which also showed Revanesse® Ultra to be equivalent to control at 6 months.
The amount of administered Revanesse® Ultra and the control drug was the same.
Opinion of cosmetologists
Cosmetologists say that Canadian fillers are excellent drugs for combating age-related skin changes. They are effective and safe.
Cosmetologists call the easy and simple administration of the gel and the minimum of side effects an undoubted advantage.
Patient and doctor satisfaction
The results are based on a single-center study of 120 patients conducted in Germany. The result of this study shows that the combination of positively charged dextran microspheres with a biologically highly compatible liquid polymeric material, such as reticulated HA with or without dextran microspheres, provided significant and effective tissue growth. Revanesse® Ultra and ReDexis® have proven their effectiveness and safety.
