Revanesse® is a line of injectable hyaluronic acid (HA) dermal fillers manufactured using state-of-the-art manufacturing techniques and optimized materials that have undergone rigorous testing and quality control.
Revanesse fillers are manufactured in Canada by Prollenium®. Currently, these are the only fillers produced in North America
Revanesse is a high-quality product, which is confirmed by a number of international regulatory organizations:
1. Manufacturing site is FDA approved (valid certificate)
2. The quality management system complies with ISO 13485:2016 standard
FDA why it matters
Revanesse® is one of 5 fillers in Russia approved by the FDA
Unique formula
- Exceptionally high quality HA
- Patented homogenization technology produces round, smooth and spherical HA particles
- Optimal cross-linking using exclusively long-chain hyaluronic acid (HA) molecules, therefore requiring less BDDE coupling agent
- Dialysis for 7 days to neutralize pH, achieve appropriate osmolality and remove residual BDDE binder and toxins.
- The finished HA gel is packaged in 1.0 ml syringes and sterilized with steam (sterilizer)
- Strict quality control throughout the entire production process
Round and smooth HA particles reduce the likelihood of an inflammatory reaction
Revanesse® fillers are formulated to the highest standards of purity.
Thanks to the use of high molecular weight HA chains, unique homogenization and binding technologies (Thixofix®), very little BDDE is required for the production of the drug.
Thus, the final degree of modification of Revanesse® does not exceed 2%
This is a guarantee of a successful procedure - no swelling and undesirable effects
Revanesse® fillers are created using Thixofix® HA crosslinking technology. The essence of the technology is that it takes as a basis such a property of substances as thixotropy. This property represents the ability of a substance to reduce viscosity (liquefy) under mechanical stress and increase viscosity (thicken) at rest.
Thanks to this technology, a cosmetologist can inject highly viscous gels using a syringe with a thin needle, without causing degradation of the modified particles.
Thixofix® technology ensures smooth and precise injection of the drug into the patient’s soft tissues
Elasticity (G') of Revanesse® fillers
G' reflects the elasticity characteristics (stiffness or resistance to deformation) of the HA gel or its ability to regain its shape after deformation (injection process)
Revanesse® products range from low G' for greater softness and ductility to high G' for greater rigidity and resistance to deformation.
The Revanesse® product line ranges from low viscosity products (thinner) to high viscosity products (less thinner) to create the desired level of volume at varying injection depths on standard areas of the face (viscosity is a measure of resistance to flow (density) under shear deformation in injection process)
revanesse® products are characterized by low levels of water absorption after injection
Water absorption is extremely important for the doctor's confidence in the implantation result.
Average swelling degree (ml/g) for Revanesse® products - 3.7
Adaptability to dynamic muscle contractions is essential for varying injection depths on standard injection areas of the face
Cohesiveness reflects an understanding of how well the gel adapts to/resists dynamic muscle contractions
revanesse® products offer optimal cohesiveness after injection
Cohesiveness is measured by weighing drug drops
Average Drop Weight (mg) for Revanesse® products: 27
Safety of use
The purity and quality of the drugs are confirmed by numerous clinical studies and safety tests, including the FDA. The main properties of HA (hyaluronic acid) used in the production of Revaness and Redexis fillers: Low protein content (less than 2 ppm) - the maximum standard of HA purity High degree of purification (0.025 EU/ML endotoxin with an acceptable 0.5 EU/ML) Monophasic HA in The composition of Revanesse ensures uniform biodegradation of the gel.
Buy Revanesse® fillers only from official distributors.
Research results
Revaness – evidence-based fillers
A multicenter, double-blind, randomized, split-face study was conducted to evaluate the safety and effectiveness of Revanesse® Ultra™
Among patients who did not violate the protocol, there was a difference between Ultra and comparator based on igai and pgai efficacy scores at 24 weeks postprocedure. The percentages reporting “much improvement” or “very much improvement” were 59.2% and 44.4% for Ultra and 47.2% and 30.6% for comparator on the iGAI and pGAI scales, respectively.
Among the total patient sample, 28.3% fewer patients reported injection site pain with Ultra compared to the other drug.
Among the total patient sample, 14.1% fewer patients reported TEAEs following a procedure performed with Ultra compared to the other agent.
Revaness line
Revanesse is a range of high HA (25 mg/ml) injectable fillers manufactured using state-of-the-art manufacturing methods and high quality materials that have undergone rigorous testing and quality control.
Revaness products are designed for:
- Correction of fine and deep wrinkles;
- Replenishment of tissue volume deficit;
- Formation and restoration of facial contours
- Volumetric modeling
- Deep skin hydration.
Comparative table of drugs
| Duration of effect in months | HA concentration mg/ml | Compound | Volume ml | |
| Revanesse | 6 | 25 | Monophasic high molecular weight HA | 2×1; 1×1 |
| Lips | 6 | 25 | Monophasic high molecular weight HA | 2×1; 1×1 |
| Ultra | 9-12 | 25 | Monophasic high molecular weight HA | |
| ReDexis | 12-18 | 25 | Monophasic high molecular weight HA, dextranomers | 2 x 1 |
| ReDexis Ultra | 18-24 | 17 | Monophasic high molecular weight HA | |
| Countour | 18-24 | 25 | Monophasic high molecular weight HA with additional ester bonds | 2×1 |
| Pure | up to 5 | 14 | Unbound high molecular weight HA | 2×1; 1×1 |
Revanesse Pure
Revanesse Pure is a non-crosslinked hyaluronic acid (14 mg/ml) presented in gel form. Homogeneous and soft Pure gel is ideal for deep hydration, restoring firmness and elasticity of the skin. Revanesse Pure can be used on the face, hands, décolleté and neck.
Revanesse Pure is equivalent to native HA, which provides deep skin nutrition. Thanks to its composition, the drug is ideal for the prevention of premature aging, as well as for deep moisturizing and biorevitalization of the skin.
Composition of Revanesse Pure
The main component of the product is thoroughly purified hyaluronic acid (there are 14 g of it here). It is diluted with phosphate buffer solution. The composition is distinguished by its monophasic structure. Due to its homogeneity, the product easily passes under the skin. The gel completely dissolves within 6-24 months.
What are the benefits of Revanesse Pure?
The drug is effective, you can see results after the first use. The manufacturer managed to develop a hypoallergenic formula. The product does not cause side effects or addiction.
This is a completely biocompatible drug. Infection is impossible, since synthesized HA is used here. The drug does not in any way affect the natural metabolism of tissues. The product will not go beyond the scope of application. The procedure for introducing the composition lasts only 15-20 minutes. The process affects only the top layer of dermal tissue. The introduction is carried out under anesthesia.
Technique of drug administration
For injections, the thinnest needles are used, which are included with the filler. The cosmetologist prints out the packaging in front of the patient and shows the quality certificate. The required area of skin is cleaned, treated with an antiseptic, and points for future injections are marked. Next, an anesthetic gel is applied to the skin, which will help reduce pain during the injection.
The composition of Revaness preparations does not require dilution with saline solution. The syringe is filled slowly and carefully to a certain depth (depending on the chosen product). For even distribution, it is recommended to massage the treated area a little.
If during injections the skin begins to turn very pale, you should immediately stop and do a light massage until the epidermis acquires a natural color. Side effects also include slight swelling and redness at the injection site, and slight pain on palpation on the first day after the injections.
How long does the effect last?
The duration of action depends on the chosen drug and the area of its application. On average, the effectiveness of the drugs in the line ranges from 6 to 24 months. After this time, biodegradation and removal of hyaluronic acid from the body occurs naturally. At the patient's request, a repeat course can be taken.
Revanesse
Revanesse has a lower viscosity compared to other fillers in the line. Homogeneous and soft, Revanesse gel is ideal for replenishing volume and correcting defects in the superficial layers of the dermis. The filler can be used for small creases, nasolabial folds, crow's feet, periorbital, glabellar folds and nasolacrimal groove. The ultra-smooth consistency of the HA gel allows it to be easily and gently injected into the dermis.
Ideal for gentle correction of superficial and shallow wrinkles
Reviews from patients and cosmetologists about Revaness fillers
Tatyana, 45 years old, Samara:
I have been using these fillers for quite some time. First I tried Revaness Kiss for lip plumping and was very pleased. Now my cosmetologist administers Revaness Contour injections, wrinkles are quickly smoothed out. The effect lasts for 2 years.
Marina, professional experience 20 years:
Most of all I like Revaness Ultra, it does a great job with nasolabial folds. The administration is simple and easy, with minimal side effects.
Anastasia, 37 years old, Moscow:
I undergo regular procedures with Revanesse Pure fillers. The skin looks younger and more vibrant, wrinkles are smoothed out. I am very pleased with the long lasting effect and relatively low price.
Revanesse Ultra
Revanesse Ultra is a high-viscosity gel with a long-term effect for the correction of deeper and more pronounced wrinkles. Smooth and viscoelastic, Ultra is ideal for filling nasolabial folds, marionette lines, deep wrinkles and creases, as well as replenishing volume in the middle third of the face. The optimal cohesiveness of the gel ensures high shape retention, which ensures long-lasting aesthetic results.
Ideal for correcting moderate to deep wrinkles.
What else should you know about Revanesse Ultra?
The composition should be highlighted separately. The product is made from hyaluronic acid, the concentration of which is 25 mg per milliliter. It also contains a phosphate buffer. This component is necessary in order to eliminate the risk of edema.
The product is produced in accordance with Thixofix technology. It increases the efficiency of GK chains, serious work has been done on the connections. As for the package, it includes 4 sterile needles, 2 syringes, several labels, instructions for use.
This drug has several significant advantages. The first thing to highlight is that it is FDA approved. The composition contains high molecular weight hyaluronic acid. Side effects are observed in less than 1% of cases. The duration of the effect is 12 months. The drug is resistant to biodegradation. There are not many contraindications. These include:
- pregnancy and breastfeeding;
- oncology;
- tendency to develop hypertrophic scars on the body;
- autoimmune diseases.
The drug must be injected into the deep layer of the dermis. The injection sites should not be touched for 12 hours. Protect the area from exposure to ultraviolet radiation.
Revanesse Contour
Revanesse Contour is a completely biodegradable transparent hyaluronic acid gel of ultra-high viscosity. It is specially designed for volumetric facial modeling. The gel is ideal for replenishing volume deficit in the middle third of the face, enlarging the cheekbones and chin, and restoring the clarity of facial contours.
Ideal for creating clear facial contours and replenishing tissue volume deficits.
Indications for use of Revanesse Contour
The product is necessary to carry out tissue reconstruction. Patients will be able to restore the natural contour of their face. With the drug you will be able to cope with defects that have arisen due to HIV-associated lipodystrophy or lipoatrophy. The product is actively used in cosmetology. With it you can restore volume, get rid of facial wrinkles, moisturize the skin, and enlarge lips. The drug allows you to overcome depression of soft tissues.
What are the contraindications for Revanesse Contour?
- Do not inject the drug into the skin around the eyes.
- The product should not be used by patients with a tendency to form scars.
- The product is prohibited for use by persons under 18 years of age.
- Revanesse Contour is not used during pregnancy or breastfeeding.
You should first discuss the use of the product with a professional cosmetologist.
