The first signs of aging are directly related to a decrease in hyaluronic acid in the skin, the main component of the intercellular matrix. Hyaluronic acid is responsible for skin turgor and elasticity. Its decline can be natural (physiological) or premature (pathological). A premature decrease in hyaluronic acid in the skin is caused by active sun exposure, chronic intoxication (for example, smoking), stress, inadequate skin care, and some somatic diseases.
To restore the concentration of hyaluronic acid in the skin, biorevitalization is used - an injection method of introducing native hyaluronic acid. The main goal of biorevitalization is to slow down the aging process.
The Fidia company (Italy) is a pioneer in the development of the concept of biorevitalization and the production of preparations for dermatocosmetology. The following drugs have been developed for practical use: Ial-System and Ial-System ACP.
1. Ial System / Ial system is a sterile visco-elastic gel based on hyaluronic acid of biosynthetic origin with a concentration of 18 mg/ml. Available in syringes with a volume of 0.6 and 1.1 ml and is one of the safest drugs for intradermal administration, which is perfectly compatible with the skin.
2. Ial System ACP is a sterile gel based on hyaluronic acid with a mesh structure, obtained using the patented “auto-cross-link” technology with a concentration of 20 mg/ml. It is available in 1.0 ml syringes. When introduced into the dermis, the drug is broken down in 2 stages. At the first stage, it absorbs water and the crosslink is destroyed with the formation of hyaluronic acid chains. In the second stage, hyaluronic acid is destroyed by the enzyme hyaluronidase, resulting in the release of fragments of hyaluronic acid of various molecular weights. The drug restores the proliferative and functional activity of fibroblasts, normalizes microcirculation of the dermis and enhances antioxidant protection.
The effect of Ial System ACP will be more pronounced in well-moisturized tissues, therefore it can be used in basic programs after Ial-System / Ial systems or in the same procedure with it.
On what areas can Ial System be used?
Ial System / Ial systems can be used on absolutely any area of the skin that needs “restoration”. As a rule, exposed areas lose tone and elasticity the fastest: face, neck, décolleté, hands. They are the ones most often exposed to ultraviolet radiation.
Biorevitalization course Ial System
A) Patients are under 30 years of age.
The course is carried out to increase skin turgor in people who abuse tanning, to prevent photoaging, before traveling to hot countries and 2 weeks after returning, as well as to correct premature wrinkles in patients with dry skin with sudden weight loss. This group uses Ial System monotherapy.
B) Age from 30-45 years.
The course is carried out with the aim of increasing skin turgor and elasticity, restoring its adaptive properties. And also during the rehabilitation period after chemical peels, laser rejuvenation, phototherapy. The primary course includes 2 Ial-System procedures, after 2 weeks Ial-System ACP, a month later - the second Ial-System ACP procedure. Maintenance course - Ial System ACP or Ial System every 4-5 months.
B) Age after 45 years.
The course is carried out with the aim of replenishing the deficiency of hyaluronic acid in the dermis, stimulating fibroblasts, and restoring microcirculation. The primary course includes 2 Ial System procedures once every 2 weeks, after 2 weeks - Ial-System ACP, after a month - again Ial System ACP. Repeated course - injections of Ial System ACP are carried out at intervals of 3-4 months. In patients with dry skin, the scheme of simultaneous administration of two drugs once a month has proven itself to be effective.
IAL-SYSTEM DUO
Olga Borisovna Rein
Dermatocosmetologist, trainer
I injected the biorevolumetric drug Ial-system DUO into patients with local volume deficiency, namely for the correction of the zygomatic region, cheek-zygomatic region, temporal region, replenishing the volume deficit in the lower third of the face - the area of the labiomental fold, nasolabial fold, correction of the shape of the chin . Ial-system DUO can be introduced both into the deep layers of the pancreas and supraperiostally (for example, in the temporal region), using a 25 G cannula. It gives a natural correction result that lasts up to 6-8 months. The uniqueness of this drug lies in its composition: in addition to stabilized HA, which gives volume, Ial-system DUO contains HA-ACP ester, which has a pronounced and prolonged stimulating effect on the cells of the dermis and hypodermis, promoting the synthesis of collagen and its own hyaluronic acid, as well as accelerating maturation preadipocytes into mature adipose tissue cells (improving the quality of subcutaneous adipose tissue). This restructuring effect occurs both on the area of the injected drug and on neighboring anatomical areas due to the diffusion of unstabilized HA. As a result, there is a pronounced improvement in skin quality - color, turgor and elasticity.
Firuza Tagiyevna Ali-Zade
Dermatocosmetologist, trainer
I have injected Ial-System DUO into patients with volume deficits in the cheek-zygomatic region, nasolabial folds, marionette lines, mental fossa, and to restore volume in the lips. Cannula and needle insertion techniques were used. When administered, the gel is easily distributed in tissues. Patients were examined after one, two and three months. All patients noted a positive result both immediately after the procedure and a significant restoration of volume and improvement in skin quality over time.
They also noted the absence of swelling and pastiness after injection. The face looks natural, at the same time fresh and young. Thanks to the structure of the drug, produced using the unique MUCH technology, my patients and I received such excellent results.
Lyudmila Igorevna Kamelina
Dermatocosmetologist, trainer
Observations of patients to whom I injected Bio-expander for a year and a half and Ial-System DUO for six months allowed me to judge the fairly wide possibilities of their use. Thus, Bio-expander, with its extreme plasticity and spreadability, behaves perfectly on skin with a reduced amount of subcutaneous fat, while significantly changing the turgor and elasticity of the skin, making it lighter. The effect of biorevitalization, in parallel with the delicate correction of volume deficiency, is observed in all patients, which is a very attractive addition to filling. The best results were observed in patients with the fine-wrinkled type of aging and “tired face” aging, as well as in young patients with local volume deficiency. The properties of the drug - to spread evenly and moisturize for a long time - make it very attractive for injection into fatty tissue on the body. Hands, earlobes, décolleté, skin above the knees, and inner thighs, when injected with a small amount of filler, significantly increase their turgor and elasticity. Ial-System DUO, with its higher viscosity, is injected deeper and is attractive for volume correction with simultaneous biorevitalization in the middle third of the face. The farther from the procedure, the brighter the effect of improving skin quality! After six months, the filling effect becomes better due to increased turgor and elasticity of the skin in nearby areas. Injections into the lower third of the face in patients with thick skin are also possible. Bio-expander and Ial-System DUO were enthusiastically received by patients and open up additional possibilities in injection contouring.
Marina Viktorovna Rusova
Dermatocosmetologist, trainer
Bio-expander and Ial-System DUO are truly a new class of drugs for restoring lost volumes! They fully correspond to scientific views on involutional processes that occur in subcutaneous fat tissue as one of the components of the skin. Unstabilized hyaluronic acid, introduced into the PFA as part of these preparations, realizes its biointeractivity, correcting age-related changes in this layer as well. As a result, both the specialist and the patient see the result immediately, and after 2-3 weeks the effect of improving quality is additionally realized and does not provoke swelling in the injection areas. When working, the preparations have good extrusion, are plastic and are perfectly distributed in tissues, which allows you to recreate soft and natural volumes and contours and avoid the “made face” phenomenon.
Using Ial System ACP and Ial System in the same procedure
The essence of the combination is the simultaneous use of two drugs, which makes it possible to use each drug in the area where it is especially needed. Ial System ACP is injected into the area around the eyes, 3-4 mm away from the ciliary edge, using microinjections using the “point by point” technique. The same technique is used on the upper eyelid. The area around the eyes is characterized by swelling, which is not a contraindication to this drug. Ial System ACP is also recommended to be administered to seborrheic areas, as it significantly reduces sebum secretion. It stimulates collagen synthesis more actively and remains in tissues longer, and the clinical effect lasts 4-6 months. All other areas are treated with the Ial System, including the neck and décolleté area. The biorevitalization procedure using two drugs is carried out once a month. The number of procedures for an intensive course ranges from 2 to 4, depending on the individual characteristics of the skin, age and maintenance of the menstrual cycle.
Maximum stimulation of fibroblasts after biorevitalization is observed from 5 to 14 days. Fibroblasts are hormone-dependent skin cells, and their activity is directly related to the concentration of estrogen during the menstrual cycle in women. The maximum level of estrogen is observed on days 12-14 of the cycle. The combination can be considered optimal when the 5th day after the biorevitalization procedure corresponds to the 12-14th day of the menstrual cycle. That is, you can achieve maximum stimulation of fibroblasts by performing the biorevitalization procedure on days 7-9 of the menstrual cycle. This is especially true for premenopausal women, i.e. during the initial period of decreased ovarian function. Endocrinologically, this period is characterized by a decrease in estrogen concentration, and clinically by a change in the interval between menstrual cycles. Premenopause begins at the age of 42-45 years, its duration is from 2 to 10 years.
Indications for use
Lack of subcutaneous fat causes hypovolumia of the face and body. This leads to loss of contours and volume deficit in various areas. The action of IAL-System DUO is aimed at solving these problems; changes are noticeable immediately after the procedure. A soft elastic gel evens out the relief and replenishes volume. It is evenly distributed in the subcutaneous space, without irregularities and bumps.
The injection solves the following problems:
- smoothes nasolabial folds and eyebrow wrinkles;
- stops the aging of the skin of the hands;
- increases lip volume;
- aligns the oval of the face in the chin and cheek-zygomatic area.
Combination of biorevitalization with other methods
1. Biorevitalization with Ial System / Ial System and Ial System ACP drugs goes well with superficial chemical peeling. After biorevitalization with Ial System 1.1, a chemical peeling procedure is performed on the 10th day. Exposure time and drug concentration are selected individually. On the 5th day after it, if the optimal level of moisture is achieved, biorevitalization is carried out with the drug Ial-System ACP. On the 10th day, chemical peeling is repeated, on the 5th day after it, the Ial System ACP procedure is performed, after 10-14 days, chemical peeling again. This combination allows you to normalize the synthesis of hyaluronic acid and collagen in the dermis, remove hyperkeratosis, pigmentation, and reduce the depth of wrinkles.
2. Biorevitalization and laser facial rejuvenation. After the fractional laser rejuvenation procedure, biorevitalization is carried out on the 14th day in order to restore the water balance of the dermis, necessary for cell division and differentiation. The use of biorevitalization allows you to shorten the rehabilitation period and get excellent results in the shortest possible time.
3. Biorevitalization and photorejuvenation potentiate each other’s action. The interval between these procedures should be 10 days. In case of rosacea, it is advisable to complete the program with a photorejuvenation procedure.
A universal treatment regimen for age-related skin changes
- Pre-peeling preparation in combination with biorevitalization.
- Peeling.
- Post-peeling rehabilitation in combination with biorevitalization.
- Botulinum toxin.
- Contour plastic.
Recommendations for skin care after the biorevitalization procedure
- During the first 24 hours after the procedure, it is not recommended to apply cosmetics and makeup; the use of the drug “Curiosin” and “Traumeel S” is allowed.
- Postpone visiting the solarium for 10-14 days, saunas and steam baths - for a week.
Contraindications to the Ial System biorevitalization procedure
- hypersensitivity to hyaluronic acid;
- pregnancy and lactation;
- active inflammatory process in the treatment area of any origin;
- tendency to form hypertrophic and keloid scars;
- taking blood thinning medications (aspirin, heparin, etc.);
- severe somatic diseases (diabetes mellitus, autoimmune processes, crisis course of hypertension, etc.);
- previously introduced synthetic implants in the treatment area.
Due to the high risk of post-inflammatory hyperpigmentation, it is not recommended to carry out the procedure earlier than 2 weeks after returning from active sun.
Pros and cons of Ial System
The procedure has many positive aspects, since the drug itself is unique in its composition and has an exceptional effect on the skin:
- after injections, gravitational and facial wrinkles are smoothed out;
- the elasticity of the skin improves, it becomes capable of extensibility;
- pores are narrowed, which relieves the skin of frequent acne and the appearance of comedones;
- the skin acquires a uniform color, without inflamed spots, even the effects of maceration become lighter and less noticeable;
- the skin texture is restored, the surface becomes smooth;
- not only the surface of the skin, but also its deep layers are saturated with moisture;
- the water balance is normalized, water is retained in especially dry places, due to which areas of peeling are eliminated;
- skin elasticity increases;
- face lift occurs;
- the visible vascular network decreases;
- natural rejuvenation occurs, since hyaluronic acid starts its own processes and activates skin metabolism;
- complexion is restored.
The undoubted advantage of biorevitalization with Ial System is the achievement of quick results. Visible changes will occur after 1-2 sessions. The skin becomes soft and velvety, tightened and well-groomed. Effective rejuvenation creates a long-lasting effect that lasts from six months to several years if you properly care for your face.
Features of the drugs
The drugs in the line differ from each other, and after consulting a specialist, the doctor will tell you which drug to buy for the patient for the procedure. In all varieties of IAL systems, the base is hyaluronic acid, which is not obtained from animals, but synthesized artificially based on bacteria, so it does not contain allergens and other risk factors. The composition of the substance is completely identical to the natural acid produced by the human body, and it also goes through a three-stage purification system.
IAL System preparations contain more hyaluronic acid compared to other products, which is the main feature of the product. In other names the average acid content is about 1.5%, and in the Italian product it is from 1.8 to 2.5%. This is significantly higher, which means it allows the substance to remain in the body longer. The basic remedy lasts for about six months, and the ACP and Duo varieties have their positive effect on average for about a year.
How does the IAL system differ from other beauty injections?
The biorevitalization procedure using the IAL System has a number of distinctive features, primarily due to the composition and effect of the drug itself. As a result of using Ial System and Ial System ACP, the skin receives not only superficial, but also deep hydration, which cannot be achieved with the use of other drugs. The drug also launches its own regeneration processes, which restore the skin. This is the most valuable effect and distinctive feature of the drugs. The exceptional results after injections will not be long in coming:
- reduction of wrinkles;
- increased skin turgor;
- restoration of a healthy complexion;
- smoothing the skin;
- antioxidant protection;
- normalization of metabolic processes at the cellular level;
- restoration of skin metabolism.
Compound
The composition of preparations with hyaluronic acid contains only the necessary components. They have all passed clinical trials and do not provoke an allergic reaction. The preparation for biorevitalization includes:
- sodium chloride;
- water;
- sodium hyaluron salt;
- monobasic and dibasic sodium phosphate.
How does the drug work?
The drug IAL System and IAL System ACP are equally effective and safe for the body. They contain stabilized hyaluronic acid, which is completely biocompatible, since in its composition and structure it is an analogue of the acid that the body produces. This is why injections are so well tolerated by patients and do not cause allergies.
Once in the skin layer, the substances activate the stimulation of collagen and elastin. These components are responsible for the skin's ability to stretch, they make it elastic and pliable, but do not cause wrinkles.
Healing period
Almost immediately after the procedure, you can return to normal life, but experts still recommend 1-2 days of rest, as well as simple restrictions on skin care. After the introduction of acid, no visible signs remain on the skin, no bumps are formed.
Absorption of hyaluronic acid occurs easily, but some sensitivity may remain for some time.
When are the results of biorevitalization visible?
The result will not keep you waiting - after just one session you can see significant changes, and after the second session, others will notice your improved appearance. The skin tightens and becomes elastic, and these changes cannot be ignored.
However, 1-2 procedures are just the start for the skin to begin to fully recover. The greatest result can be achieved after the end of the session through 4-5 injection procedures, when the skin is saturated with water in sufficient quantities and the regeneration processes are launched in full. This is confirmed by reviews of patients who have completed a full course of biorevitalization.
Indications
- Dry skin.
- Finely wrinkled skin
- Age-related changes.
- Dehydrated, dull skin
- Gray skin color
- Recovery after aggressive procedures, such as Fraxel
- Prevention of photoaging (2 weeks before the sea and two weeks after sunbathing)
- Hyperpigmentation
As for side effects, very rarely minor swelling or redness appears in the areas of drug administration due to dilation of the dermal vessels. The phenomena pass quite quickly. Sometimes hematomas occur at the injection sites. After 3-4 days, no traces of the bruises remain.
